A Basis for the Decision to Rule in or out Acetaminophen Toxicity: Assessment of the Serum Level Within 4 Hours Post Overdose

Background: Acetaminophen is a popular antipyretic and analgesic medication worldwide; however, its therapeutic window narrow, which may lead to overdose or toxicity. This study was conducted assess the correlation between serum acetaminophen levels before 4 hours after acute toxicity with this drug. The objective of test validity level arrive at clinical decision on acetaminophen. Methods: cross-sectional performed patients hospitalized treated diagnosis during one year (Sept. 2018 Sept. 2019) Toxicology Department Imam Reza Hospital, Mashhad, Iran. Patients were analyzed for demographics, time ingestion, their first second concentrations. Results: A total 204 (106 male & 98 female) included in study. average dose ingestion by these 14.5±3.50 g all successfully N-Acetyl-Cysteine (NAC). variables age (P=0.293), 1-2 h (P=0.679), 2-3 (P=0.126) did not have significant relationships fourth hour. However, tested 3-4 intoxication dosage had Conclusion: In toxicity, data obtained 4-hour timepoint from useful decide need rescue treatment N-acetyl-cysteine.